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KMID : 0360919610040100060
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Journal of the Korean Medical Association
1961 Volume.4 No. 10 p.60 ~ p.72
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The Experimental Studies on the Influence fo Galic to the Adrenal Gland and to the Blood in Rats
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Abstract
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Garlic (Allium Scorodoplasm) contains a volatile substance called allicin which has antibiotic and antitumor effects. Garlic has various pharmaceutical effect and causes biochemical changes when administered to animals and humans in an attempt to find any effect of garlic on an adrenal function, garlic and its ether extract were administered to rats and urinary 17-ketosteroids, weight of adrenal gland and its vitamin C content were determined. Also uropepsin, acid and pepsin in stomach contents and hemeglobin were investigated. Garlic polysaccharide was extracted and its effect on prothrombin time was investigated.
The results were as follows:
(1) Garlic has no effect on urinary 17I-ketosteroids output the weight of adrenal gland and its vitamin C content when garlic was administered peros.
(2) Ether extract of garlic increased considerablly the urinary 17-ketosteroids and the weight of the adrenal gland when administered parenterally.
(3) Ether extract of garlic caused more anemic effect than the garlic itself.
(4) a garlic may stimulate the stomach increasing the excretion of the acid and. the pepsin.
(5) Polysaccharide extracted from the garlic prolonged the prothrombin time.
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